化工社化工社 化学情報印刷レポート · 研究参考用
m-Nitroacetophenone → alpha-Methyl-3-nitrobenzenemethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-Nitroacetophenone | HCID 8494 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | alpha-Methyl-3-nitrobenzenemethanol | HCID 223135 | — |
反応手順
26.4 g (160 mmol) of 1-(3-nitrophenyl)ethanone are suspended in 270 ml of methanol, and 6.1 g (160 mmol) of sodium borohydride are added in portions with ice cooling. The reaction mixture is subsequently stirred for a further 3 h without cooling, diluted with 300 ml of dichloromethane and washed with 3×200 ml of water. The organic phase is dried over sodium sulfate and evaporated to dryness.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08071593B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-68cae19d5e03440abae9b8c78f7b0c6c |
| 出典メモ | uspto-grants-2011_12 |