m-Nitroacetophenone → alpha-Methyl-3-nitrobenzenemethanol

HRID 655313

反応式

HRID 655313 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[BH4-].[Na+]>CO.ClCCl>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([OH:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

参加物

5

反応物 2

HCID 8494m-NitroacetophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 223135alpha-Methyl-3-nitrobenzenemethanol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

26.4 g (160 mmol) of 1-(3-nitrophenyl)ethanone are suspended in 270 ml of methanol, and 6.1 g (160 mmol) of sodium borohydride are added in portions with ice cooling. The reaction mixture is subsequently stirred for a further 3 h without cooling, diluted with 300 ml of dichloromethane and washed with 3×200 ml of water. The organic phase is dried over sodium sulfate and evaporated to dryness.

後処理

  1. temperaturewithout cooling
  2. washwashed with 3×200 ml of water
  3. dry with materialThe organic phase is dried over sodium sulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-68cae19d5e03440abae9b8c78f7b0c6c
出典データセット
uspto-grants-2011_12
特許番号
US08071593B2

関連ノート

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