関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5,6-difluorobenzo[d]oxazol-2(3H)-one | HCID 11535637 | — |
| 反応物 | 1-(1-Bromoethyl)-3-nitrobenzene | HCID 22917838 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | tert-Butyl methyl ether | HCID 15413 | — |
| 生成物 | HCID 58485966 | HCID 58485966 | — |
反応手順
500 mg (2.9 mmol) of 5,6-difluoro-3H-benzoxazol-2-one, 672 mg (2.9 mmol) of (1-bromoethyl)-3-nitrobenzene and 1.58 g (11.4 mmol) of potassium carbonate are suspended in 6 ml of acetonitrile, and the mixture is stirred at 60° C. for 6 h. The mixture is subsequently diluted with 30 ml of MTBE, washed with 3×20 ml of H2O, dried over sodium sulfate and evaporated to dryness. The crude product is purified by column chromatography on silica gel.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08071593B2 |
|---|
| 出典データセット | uspto-grants-2011_12 |
|---|
| ORD ID | ord-ff1007f86899409681298a51883ce4ec |
|---|
| 出典メモ | uspto-grants-2011_12 |
|---|
