Phosphorus oxychloride → 2-Chloro-4-(4-fluorobenzoyl)-pyridine

HRID 65532ノート

反応式

HRID 65532 の反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][N+:11]([O-])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:19]>>[Cl:19][C:12]1[CH:13]=[C:8]([C:6](=[O:7])[C:5]2[CH:15]=[CH:16][C:2]([F:1])=[CH:3][CH:4]=2)[CH:9]=[CH:10][N:11]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 541432034-(4-fluorobenzoyl)-pyridine N-oxide

生成物 1

HCID 201457102-Chloro-4-(4-fluorobenzoyl)-pyridine

実験手順

0.88 g 4-(4-fluorobenzoyl)-pyridine N-oxide and 50 ml POCl3 are refluxed for 2 hrs. Excess POCl3 is distilled at normal pressure. The crude is treated with slightly alkaline cold water and then extracted with methylene chloride. Working as usual affords 0.80 g of title product, identical with that obtained by the Friedel-Crafts process (see Ex. 3d).

後処理

  1. distillationExcess POCl3 is distilled at normal pressure
  2. additionThe crude is treated with slightly alkaline cold water
  3. extractionextracted with methylene chloride

出典と根拠

ORDレコード
ord-b36102e79113467b91a9a346fad3538f
出典データセット
uspto-grants-1986_09
特許番号
US04614833

反応ノート

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