3-Ethoxy-2-methylacrylaldehyde → Methyl 3-(5-methylpyrimidin-2-yl)benzoate

HRID 655322ノート

反応式

HRID 655322 の反応式
C(O)(=O)C.[C:5]([C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=1)[C:11]([O:13][CH3:14])=[O:12])(=[NH:7])[NH2:6].CCO/[CH:21]=[C:22](/[CH:24]=O)\[CH3:23].C[O-].[Na+]>CO>[CH3:24][C:22]1[CH:21]=[N:7][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][CH:17]=2)[C:11]([O:13][CH3:14])=[O:12])=[N:6][CH:23]=1

参加物

5

反応物 3

HCID 30848683-Ethoxy-2-methylacrylaldehydeHCID 10942334Sodium MethoxideHCID 66985510HCID 66985510、化合物

生成物 1

HCID 59484867Methyl 3-(5-methylpyrimidin-2-yl)benzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

反応条件

温度
50 °C

実験手順

2.41 g (10 mmol) of methyl 3-carbamimidoylbenzoate acetate are suspended in 40 ml of methanol, 1.31 ml (11 mmol) of 3-ethoxymethacrolein and 2.04 ml of 30% sodium methoxide in methanol are added, and the mixture is stirred at 50° C. for 15 h. The reaction mixture is evaporated to dryness, and 100 ml of water are added. The precipitate formed is filtered off with suction and dried in vacuo. The crude product is reacted further without further purification; product: 1.65 g; ESI: 229 (M+H).

後処理

  1. customThe reaction mixture is evaporated to dryness, and 100 ml of water
  2. additionare added
  3. customThe precipitate formed
  4. filtrationis filtered off with suction
  5. customdried in vacuo
  6. customThe crude product is reacted further without further purification

出典と根拠

ORDレコード
ord-339f188cbf48461193f25796b8645b08
出典データセット
uspto-grants-2011_12
特許番号
US08071593B2

反応ノート

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