Hydrochloric Acid → 1-(1-Benzothiophen-4-yl)piperazine hydrochloride

HRID 655635ノート

反応式

HRID 655635 の反応式
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 210731871-(Benzo[b]thiophen-4-yl)piperazine

生成物 1

HCID 574825411-(1-Benzothiophen-4-yl)piperazine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Then, 3.7 ml of concentrated hydrochloric acid was added to a methanol solution of 9.5 g of 1-benzo[b]thiophen-4-yl-piperazine, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the obtained residue and precipitated crystals were obtained by filtration. Recrystallization was performed from methanol to obtain 1-benzo[b]thiophen-4-yl-piperazine hydrochloride as colorless needle-like crystals.

後処理

  1. customthe solvent was evaporated under reduced pressure
  2. additionEthyl acetate was added to the obtained residue
  3. customprecipitated crystals
  4. customwere obtained by filtration
  5. customRecrystallization

出典と根拠

ORDレコード
ord-b46f908a3ccb4f26adb9e601a1172dab
出典データセット
uspto-grants-2011_12
特許番号
US08071600B2

反応ノート

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