2-(1-hydroxyethyl)pyrimidin-4(3H)-one → 2-Acetylpyrimidin-4(1H)-one

HRID 655780ノート

反応式

HRID 655780 の反応式
[OH:1][CH:2]([C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][N:5]=1)[CH3:3]>ClC(Cl)C.[O-2].[O-2].[Mn+4]>[C:2]([C:4]1[NH:9][C:8](=[O:10])[CH:7]=[CH:6][N:5]=1)(=[O:1])[CH3:3]

参加物

4

反応物 1

HCID 110189492-(1-hydroxyethyl)pyrimidin-4(3H)-one2 回

生成物 1

HCID 221217222-Acetylpyrimidin-4(1H)-one収率 32.6%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 63651,1-Dichloroethane溶媒

反応条件

温度
90 °C

実験手順

To a stirred solution of 2-(1-hydroxyethyl)pyrimidin-4(3H)-one (Intermediate 50, 5 g, 35.71 mmol) in dichloroethane (200 mL), manganese dioxide (31 g, 357.1 mmol) was added. The reaction mixture was heated to 90° C. for 5 h. The reaction mixture was filtered through a celite bed and washed with dichloroethane (60 mL). The filtrate was concentrated to dryness to yield 1.6 g (32.6%) 2-acetylpyrimidin-4(3H)-one.

後処理

  1. filtrationThe reaction mixture was filtered through a celite bed
  2. washwashed with dichloroethane (60 mL)
  3. concentrationThe filtrate was concentrated to dryness

出典と根拠

ORDレコード
ord-ecb4cbdcff4140c6b39aa007195949d3
出典データセット
uspto-grants-2011_12
特許番号
US08071605B2

反応ノート

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