Hydrochloric Acid → HCID 68820112、化合物
反応式
C(OC([N:8]([C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH:20]=[CH:19][CH:18]=[CH:17]2)=[CH:12][CH:11]=1)[NH2:9])=O)(C)(C)C.O1CCOCC1.[ClH:27]>C(Cl)Cl>[ClH:27].[N:16]1([C:13]2[CH:14]=[CH:15][C:10]([NH:8][NH2:9])=[CH:11][CH:12]=2)[CH:17]=[CH:18][CH:19]=[CH:20]1参加物
5
実験手順
Title compound 50A, N-(4-Pyrrol-1-yl-phenyl)-hydrazinecarboxylic acid tert-butyl ester (0.32 g, 1.0 eq, 1.2 mmol) was suspended in a mixture of 4M HCl in Dioxane (4.9 ml, 17.0 eq, 19.7 mmol) and DCM (5 ml). The mixture was then stirred at room temperature for 24 hr solvent was then removed in vacuo to yield the title compound as an off-white solid (0.25 g, 1.12 mmol, 95%). LCMS: [M+H]+=157/174, rt=0.98 min, 98% purity.
後処理
- customwas then removed in vacuo
出典と根拠
- ORDレコード
- ord-77fad973892549f29eba5e7eff08c500
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071607B2
反応ノート
読み込み中…