Hydrochloric Acid → (4-Pyrazol-1-yl-phenyl)-hydrazine Hydrochloride

HRID 655866ノート

反応式

HRID 655866 の反応式
C(OC([N:8]([C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH:20]=[CH:19][CH:18]=[N:17]2)=[CH:12][CH:11]=1)[NH2:9])=O)(C)(C)C.O1CCOCC1.[ClH:27]>C(Cl)Cl>[ClH:27].[N:16]1([C:13]2[CH:14]=[CH:15][C:10]([NH:8][NH2:9])=[CH:11][CH:12]=2)[CH:20]=[CH:19][CH:18]=[N:17]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68820898N-(4-Pyrazol-1-yl-phenyl)-hydrazinecarboxylic Acid tert-butyl Ester

生成物 1

HCID 68824303(4-Pyrazol-1-yl-phenyl)-hydrazine Hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Title compound 51A, N-(4-Pyrazol-1-yl-phenyl)-hydrazinecarboxylic acid tert-butyl ester (0.42 g, 1.0 eq, 1.53 mmol) was suspended in a mixture of 4M HCl in Dioxane (6.5 ml, 17.0 eq, 26 mmol) and DCM (5 ml). The mixture was then stirred at room temperature for 24 hours solvent was then removed in vacuo to yield impure title compound. (0.31 g). LCMS: [M+H]+=158/175, 65% purity.

後処理

  1. customwas then removed in vacuo

出典と根拠

ORDレコード
ord-2f4bf8455d0a404b990f424296af13c9
出典データセット
uspto-grants-2011_12
特許番号
US08071607B2

反応ノート

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