Hydrochloric Acid → 4-Cyanophenylhydrazine Hydrochloride
反応式
C(OC([N:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=1)[NH2:9])=O)(C)(C)C.O1CCOCC1.[ClH:24]>C(Cl)Cl>[ClH:24].[NH:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=1)[NH2:9]参加物
5
実験手順
Title compound 52A, N-(4-cyano-phenyl)-hydrazinecarboxylic acid tert-butyl ester (0.23 g, 1.0 eq, 0.99 mmol) was suspended in a mixture of 4M HCl in Dioxane (4.2 ml, 17.0 eq, 16.8 mmol) and DCM (5 ml). The mixture was then stirred at room temperature for 18 hours The resultant precipitate was isolated by filtration and washed with DCM to yield the title compound as a cream solid. (0.14 g, 0.8 mmol, 85%). 1H NMR (DMSO) 400 MHz: Indicates product in >95% purity
後処理
- customwas isolated by filtration
- washwashed with DCM
出典と根拠
- ORDレコード
- ord-c859f5cb14dc4d8f84fc86e38cdd5bb9
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071607B2
反応ノート
読み込み中…