Selenium Dioxide → 5-Bromo-6-methoxy-2-quinolinecarbaldehyde

反応式

[Br:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:14])=[N:7]2.[Se](=O)=[O:16]>>[Br:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH:14]=[O:16])=[N:7]2

参加物

反応物 2

HCID 24007Selenium Dioxide

HCID 114252565-Bromo-6-methoxy-2-methylquinoline

生成物 1

HCID 575169515-Bromo-6-methoxy-2-quinolinecarbaldehyde収率 75%

実験手順

The title compound was prepared from 5-bromo-6-methoxy-2-methylquinoline (6b) and selenium dioxide using methods as described in the literature for similar compounds (Mathes et al., 1957) in 75% yield. 1H NMR (DMSO-d6, HMDSO), δ: 4.07 (3H, s); 7.92 (1H, d, J=9.0 Hz); 8.03 (1H, d, J=9.2 Hz); 8.29 (1H, d, J=9.2 Hz); 8.58 (1H, d, J=9.0 Hz), 10.09 (3H, s).

出典と根拠

ORDレコード: ord-f05654ec13ed4363be9af5af93ef0de8
出典データセット: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08071620B2

反応ノート

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