Selenium Dioxide → 6-Fluoroquinoline-2-carbaldehyde

反応式

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[CH:5]2.[Se](=O)=[O:14]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH:12]=[O:14])[CH:6]=[CH:5]2

参加物

反応物 2

HCID 24007Selenium Dioxide

HCID 707846-Fluoro-2-methylquinoline

生成物 1

HCID 31596056-Fluoroquinoline-2-carbaldehyde収率 70%

実験手順

The title compound was prepared from 6-fluoro-2-methylquinoline (6e) and selenium dioxide using methods as described in the literature for similar compounds (Barbier et al., 2000) in 70% yield.

出典と根拠

ORDレコード: ord-76e09acc68c541f5b96f7f6bb9a4d3e1
出典データセット: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08071620B2

反応ノート

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