Ethanol → Ethyl 2-[4-(2-fluorophenoxy)phenyl]propionate

HRID 65593ノート

反応式

HRID 65593 の反応式
[F:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH3:15])[C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1.S(=O)(=O)(O)O.[CH2:25](O)[CH3:26]>>[F:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([CH:11]([CH3:15])[C:12]([O:14][CH2:25][CH3:26])=[O:13])=[CH:9][CH:10]=1

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 205597862-[4-(2-Fluorophenoxy)phenyl]propionic acid

生成物 1

HCID 22757306Ethyl 2-[4-(2-fluorophenoxy)phenyl]propionate

実験手順

2-[4-(2-Fluorophenoxy)phenyl]propionic acid (2.32 g.) in ethanol (16 ml.) containing concentrated sulfuric acid (0.5 ml.) were refluxed for 5 hours and the alcohol removed. After dilution with water the product was isolated in ether and distilled to give ethyl 2-[4-(2-fluorophenoxy)phenyl]propionate, b.p. 176°-177° C./2.5 mm.

後処理

  1. temperaturewere refluxed for 5 hours
  2. customthe alcohol removed
  3. customAfter dilution with water the product was isolated in ether
  4. distillationdistilled

出典と根拠

ORDレコード
ord-33bd4a495d2f4ef996180e7466d31fac
出典データセット
uspto-grants-1978_12
特許番号
US04128573

反応ノート

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