Hydrochloric Acid → HCID 70166468、化合物

HRID 65594ノート

反応式

HRID 65594 の反応式
[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH:8]C(OCC1C=CC=CC=1)=O.[ClH:31].[H][H]>CO>[ClH:31].[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH2:8]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 13190522Z-Ser-Tyr-OMeHCID 178418361HCID 178418361、化合物

生成物 1

HCID 70166468HCID 70166468、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a mixture consisting of 4.16 g. of N-benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [for the preparation of this compound see J. Am. Chem. Soc., 76, 5076 (1954)], 30 ml. of methanol, and 416 mg. of 5% palladium-on-barium sulfate is added 8.7 ml. of methanol containing 400 mg. of hydrogen chloride, and hydrogen is passed over the stirred mixture for 75 minutes. The mixture is then filtered to remove the catalyst, and the filtrate is evaporated to dryness under reduced pressure to give a solid residue of L-seryl-L-tyrosine methyl ester hydrochloride, which is suitable for use without further purification.

後処理

  1. filtrationThe mixture is then filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-a43679a8b75349c3aad8097a4b646581
出典データセット
uspto-grants-1978_12
特許番号
US04128540

反応ノート

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