Hydrazine → 3-amino-N-(2-chlorobenzyl)-2,2-dimethylpropanamide

HRID 655959ノート

反応式

HRID 655959 の反応式
[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[CH2:4][NH:5][C:6](=[O:22])[C:7]([CH3:21])([CH3:20])[CH2:8][N:9]1C(=O)C2C(=CC=CC=2)C1=O.NN>CO>[NH2:9][CH2:8][C:7]([CH3:21])([CH3:20])[C:6]([NH:5][CH2:4][C:3]1[CH:23]=[CH:24][CH:25]=[CH:26][C:2]=1[Cl:1])=[O:22]

参加物

4

反応物 2

HCID 9321HydrazineHCID 59778496N-(2-chlorobenzyl)-3-(1,3-dioxoisoindolin-2-yl)-2,2-dimethylpropanamide

生成物 1

HCID 597784043-amino-N-(2-chlorobenzyl)-2,2-dimethylpropanamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N-(2-chlorobenzyl)-3-(1,3-dioxoisoindolin-2-yl)-2,2-dimethylpropanamide (0.50 g, 1.35 mmol) in methanol (5 mL) was added hydrazine (423 μL, 13.5 mmol, 10 equiv.). The reaction mixture was stirred overnight. The crude mixture was concentrated. The resulting residue was dried in vacuum to give 3-amino-N-(2-chlorobenzyl)-2,2-dimethylpropanamide, which was used without further purification. LRMS (M+H+) m/z 241.1.

後処理

  1. concentrationThe crude mixture was concentrated
  2. customThe resulting residue was dried in vacuum

出典と根拠

ORDレコード
ord-2e839ab4901d47c09e9a17f884e7b1dc
出典データセット
uspto-grants-2011_12
特許番号
US08071625B2

反応ノート

読み込み中…