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Diethanolamine → 3-(2-Chlorobenzyl)-1,1-bis(2-hydroxyethyl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethanolamine | HCID 8113 | — |
| 反応物 | 1-Chloro-2-(isocyanatomethyl)benzene | HCID 2733367 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(2-Chlorobenzyl)-1,1-bis(2-hydroxyethyl)urea | HCID 59778457 | 65% |
反応手順
To a solution of 2,2′-azanediyldiethanol (1.58 g, 15 mmol) in DMF (5 mL) was added 2-chlorobenzylisocyanate (1.26 g, 7.5 mmol). The reaction mixture was stirred at rt for 30 min. The mixture was purified on RP-HPLC using a mixture of acetonitrile and H2O to give 3-(2-chlorobenzyl)-1,1-bis(2-hydroxyethyl)urea (1.3 g, 65%). LRMS (M+H+) m/z 272.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08071625B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-46d84a61a1c84e329df5d6a6fdb210e1 |
| 出典メモ | uspto-grants-2011_12 |