Methylamine → HCID 66707598、化合物

HRID 656222ノート

反応式

HRID 656222 の反応式
[CH3:1][NH2:2].C[O:4][C:5](=O)[CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1>CO>[CH:8]1([CH2:7][CH2:6][C:5]([NH:2][CH3:1])=[O:4])[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1

参加物

4

反応物 2

HCID 6329Methylamine2 回HCID 12772855Methyl 3-(cyclohex-3-en-1-yl)propanoate

生成物 1

HCID 66707598HCID 66707598、化合物収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl amine (8 M in EtOH, 75 ml, 600 mmol) was added to a mixture of 3-cyclohex-3-enyl-propionic acid methyl ester (German patent DE 4023848 A1 19920130) (20.0 g, 119 mmol) in 75 mL of methanol. The mixture was stirred at room temperature for one day. Additional Methyl amine (8 M in EtOH, 40 ml, 320 mmol) was added to the mixture and stirring continued for one more day. The mixture was concentrated and the residue was taken up in ethyl acetate, washed with 0.5 M aqueous HCl, dried and stripped of the solvent to give the title compound (19.50 g, 98% yield, uncorrected) as a pale orange solid.

後処理

  1. stirringstirring
  2. concentrationThe mixture was concentrated
  3. washwashed with 0.5 M aqueous HCl
  4. customdried

出典と根拠

ORDレコード
ord-f8a95b11120a458fa867e3bbf86e5931
出典データセット
uspto-grants-2011_12
特許番号
US08071643B2

反応ノート

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