6-Methoxy-2-hexanone → HCID 86639839、化合物

HRID 656239ノート

反応式

HRID 656239 の反応式
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](=[O:9])[CH3:8].[Cl-:10].[Li+]>CN(C)C=O.O.[Cu](Cl)Cl>[Cl:10][CH:6]([CH2:5][CH2:4][CH2:3][O:2][CH3:1])[C:7](=[O:9])[CH3:8]

参加物

5

反応物 2

HCID 344156-Methoxy-2-hexanoneHCID 433294Lithium Chloride

生成物 1

HCID 86639839HCID 86639839、化合物

試薬・触媒・溶媒 2

HCID 16219111Copper(II) chloride dihydrate触媒HCID 6228Dimethylformamide溶媒2 回

反応条件

温度
85 °C

実験手順

1.5 mol of 6-methoxyhexan-2-one [29006-00-6] are added to a mixture of 3.6 mol of copper(II) chloride hydrate and 1.8 mol of lithium chloride in 900 ml of N,N-dimethylformamide at 80° C. The reaction mixture is stirred at 80-90° C. for 1 hour. 900 g of ice are added, and the precipitate is dissolved by adding N,N-dimethylformamide. Extraction with pentane (6×) is carried out. The combined organic phases are washed with water, dried over sodium sulphate and fractionated in vacuo. The title compound is identified by means of the Rf.

後処理

  1. dissolutionthe precipitate is dissolved
  2. extractionExtraction with pentane (6×)
  3. washThe combined organic phases are washed with water
  4. dry with materialdried over sodium sulphate

出典と根拠

ORDレコード
ord-74c7c43ec2a34bb98c762563df4e4925
出典データセット
uspto-grants-2011_12
特許番号
US08071651B2

反応ノート

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