Diazomethane → Methyl 6-bromo-3-methoxypicolinate
反応式
[N+](=[CH2:3])=[N-].[Br:4][C:5]1[N:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[C:8]([OH:15])=[CH:7][CH:6]=1>C(OCC)C.CO>[Br:4][C:5]1[N:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[C:8]([O:15][CH3:3])=[CH:7][CH:6]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
A solution of diazomethane in diethyl ether (about 0.4 M) is added in excess to a solution of 2.3 mmol of methyl 6-bromo-3-hydroxypyridine-2-carboxylate [321601-48-3] in 30 ml of methanol at 0° C. The mixture is stirred at 0° C. for 2 hours, then quenched with magnesium sulphate, filtered and evaporated. The crude title compound is identified by means of the Rf.
後処理
- customquenched with magnesium sulphate
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-1ca5ff9f07c24d21bca5e246b7fb6232
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071651B2
反応ノート
読み込み中…