Diazomethane → rac-methyl (3R,5S)-5-hydroxyoxane-3-carboxylate
反応式
[N+](=[CH2:3])=[N-].[OH:4][C@H:5]1[CH2:10][O:9][CH2:8][C@@H:7]([C:11]([OH:13])=[O:12])[CH2:6]1>C(OCC)C.CO>[OH:4][C@H:5]1[CH2:10][O:9][CH2:8][C@@H:7]([C:11]([O:13][CH3:3])=[O:12])[CH2:6]1参加物
5
反応条件
- 温度
- 0 °C
実験手順
A solution of diazomethane in diethyl ether (approx. 0.4 M) is added in excess to a solution of 23 mmol of (cis)-5-hydroxytetrahydropyran-3-carboxylic acid in 300 ml of methanol at 0° C. The mixture is stirred at 0° C. for 2 hours and then quenched with magnesium sulphate, filtered and evaporated. The crude title compound is identified by means of the Rf.
後処理
- customquenched with magnesium sulphate
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-1e55ef36458c48b4ac63172872a7f8d4
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071651B2
反応ノート
読み込み中…