4-Amino-2,5-difluorobenzonitrile → 4-(Aminomethyl)-2,5-difluoroaniline

4-amino-2,5-difluorobenzonitrile (400 mg) and Raney nickel Catalyst were added to methanol (20 ml) and the mixture was stirred under hydrogen atmosphere at room temperature for 18 hours. After confirming the completion of the reaction, the resulting mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The following procedure was carried out, using the concentrate which was not purified.

1. customthe completion of the reaction
2. filtrationthe resulting mixture was filtered through celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. concentrationconcentrate which
5. customwas not purified

ORDレコード

ord-741b233ad0c846098ea527fb4bc75a45

出典データセット

uspto-grants-2011_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08071650B2