Furfurylamine → 1-(Furan-2-ylmethyl)-3-(4-methoxybenzyl)thiourea

HRID 656283ノート

反応式

HRID 656283 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH2:7].C(N(CC)CC)C.[CH3:15][O:16][C:17]1[CH:26]=[CH:25][C:20]([CH2:21][N:22]=[C:23]=[S:24])=[CH:19][CH:18]=1>CN(C)C=O.C(OCC)(=O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][C:23]([NH:22][CH2:21][C:20]1[CH:25]=[CH:26][C:17]([O:16][CH3:15])=[CH:18][CH:19]=1)=[S:24]

参加物

6

反応物 3

HCID 3438FurfurylamineHCID 8471TriethylamineHCID 1231974-Methoxybenzyl isothiocyanate

生成物 1

HCID 9781801-(Furan-2-ylmethyl)-3-(4-methoxybenzyl)thiourea収率 92.5%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Furan-2-ylmethylamine (190 mg) was dissolved in dimethylformamide (5 ml) and to the solution were added triethylamine (200 mg) and 4-methoxybenzylisothiocyanate (360 mg), followed by stirring at room temperature for 24 hours. Then, the resulting mixture was diluted with ethyl acetate, washed with water, dried, and concentrated under reduced pressure. The residue was purified by column-chromatography (hexane/ethyl acetate=1/1) to yield the compound 16-1 (0.5 g, 90%) as a liquid.

後処理

  1. washwashed with water
  2. customdried
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by column-chromatography (hexane/ethyl acetate=1/1)

出典と根拠

ORDレコード
ord-4aed6ed970074ad2abed7d319ea0de3c
出典データセット
uspto-grants-2011_12
特許番号
US08071650B2

反応ノート

読み込み中…