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(1-methyl-1H-pyrrol-2-yl)methanamine → 1-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1-methyl-1H-pyrrol-2-yl)methanamine | HCID 2776207 | — |
| 反応物 | 1-Tert-butyl-4-(isothiocyanatomethyl)benzene | HCID 14801041 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea | HCID 59088065 | 75.9% |
反応手順
(1-methyl-1H-pyrrol-2-yl)methylamine (65 mg) and 4-t-butylbenzylisothiocyanate (120 mg) were dissolved in ethyl acetate (30 ml) and the solution was stirred for 12 hours. After the completion of the reaction, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3) to yield the compound 17-2 (140 mg, 75%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08071650B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-ad0f65674d824e39a75806ea578f636e |
| 出典メモ | uspto-grants-2011_12 |