Dimethyldioxirane → 2-Oxo-3-(2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)propanal

HRID 656419ノート

反応式

HRID 656419 の反応式
N=[CH:2][C:3](=[O:21])[CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[C:6]1=[O:20].CC1(C)O[O:24]1>CC(C)=O>[O:21]=[C:3]([CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[N:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[C:6]1=[O:20])[CH:2]=[O:24]

参加物

4

反応物 2

HCID 115197DimethyldioxiraneHCID 866322931-(3-Imino-2-oxopropyl)-3-pyridin-2-yl-1,3-dihydro-2H-benzimidazol-2-one

生成物 1

HCID 574361812-Oxo-3-(2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)propanal

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a stirred solution of 1-(3-imino-2-oxopropyl)-3-pyridin-2-yl-1,3-dihydro-2H-benzimidazol-2-one from Step A (54 mg, 0.19 mmol) in acetone (2 mL) at 0° C. was added a solution of dimethyldioxirane (0.02 M in acetone, 9.6 mL, 0.19 mmol). The reaction mixture was stirred for 90 min then concentrated in vacuo to give the title compound in sufficient purity for use in the next step.

後処理

  1. concentrationthen concentrated in vacuo

出典と根拠

ORDレコード
ord-1ffb6a63911c4ee8aa1813e7260f42c5
出典データセット
uspto-grants-2011_12
特許番号
US08071771B2

反応ノート

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