2-(2-Amino-5-bromophenyl)acetonitrile → 4-Amino-3-cyanomethyl-benzonitrile

HRID 656504ノート

反応式

HRID 656504 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[CH:4][C:3]=1[CH2:9][C:10]#[N:11].[Cu][C:13]#[N:14]>CN1CCCC1=O.O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:13]#[N:14])=[CH:4][C:3]=1[CH2:9][C:10]#[N:11]

参加物

5

反応物 2

HCID 450370522-(2-Amino-5-bromophenyl)acetonitrileHCID 178418546HCID 178418546、化合物

生成物 1

HCID 574685124-Amino-3-cyanomethyl-benzonitrile

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

2 mmol of (2-Amino-5-bromo-phenyl)-acetonitrile [882855-95-0] and 4 mmol of copper (I) cyanide are heated at 200° C. in 2 ml of N-methylpyrrolidinone for 4 h. After cooling to room temperature, the solution is diluted with water and extracted with ethyl acetate (3×). The organic layer is separated, dried over magnesium sulphate and evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60F) on the basis of the Rf value.

後処理

  1. extractionextracted with ethyl acetate (3×)
  2. customThe organic layer is separated
  3. dry with materialdried over magnesium sulphate
  4. customevaporated

出典と根拠

ORDレコード
ord-f3c9c2b3802e4bf897b90a1d94cf78ed
出典データセット
uspto-grants-2011_12
特許番号
US08071774B2

反応ノート

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