Water → HCID 59799786、化合物

HRID 656550ノート

反応式

HRID 656550 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]([NH2:15])=[N:12][O:13][N:14]=2)=[CH:6][CH:5]=1)([O-])=O.[Sn](Cl)Cl.O>C(OCC)(=O)C>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[C:11]([NH2:15])=[N:12][O:13][N:14]=2)=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 962WaterHCID 24479Stannous ChlorideHCID 14021895HCID 14021895、化合物

生成物 1

HCID 59799786HCID 59799786、化合物収率 94%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

4-(4-Nitrophenyl)-1,2,5-oxadiazol-3-amine (0.500 g, 2.42 mmol), tin dichloride (1.61 g, 8.49 mmol), and water (0.306 mL, 17.0 mmol) were combined in ethyl acetate (20 mL) in a round bottom flask, and the mixture was stirred at room temperature overnight. The solvent was removed and methylene chloride was added, and the mixture was washed three times with aqueous NaOH. The organic phase was dried over MgSO4, filtered, and concentrated to afford the title compound as a yellow solid (400 mg, 94%).

後処理

  1. customThe solvent was removed
  2. additionmethylene chloride was added
  3. washthe mixture was washed three times with aqueous NaOH
  4. dry with materialThe organic phase was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-25e32bbf1015429db1e12b1036b00feb
出典データセット
uspto-grants-2011_12
特許番号
US08071779B2

反応ノート

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