Benzaldehyde, 3-(2-hydroxyethoxy)- → 2-(3-((3-(Isoquinolin-5-ylamino)pyrrolidin-1-yl)methyl)phenoxy)ethanol

反応式

[NH:1]1[CH2:5][CH2:4][CH:3]([NH:6][C:7]2[C:8]3[CH:9]=[CH:10][N:11]=[CH:12][C:13]=3[CH:14]=[CH:15][CH:16]=2)[CH2:2]1.[OH:17][CH2:18][CH2:19][O:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH:24]=O>>[CH:12]1[C:13]2[C:8](=[C:7]([NH:6][CH:3]3[CH2:4][CH2:5][N:1]([CH2:24][C:23]4[CH:22]=[C:21]([CH:28]=[CH:27][CH:26]=4)[O:20][CH2:19][CH2:18][OH:17])[CH2:2]3)[CH:16]=[CH:15][CH:14]=2)[CH:9]=[CH:10][N:11]=1

参加物

反応物 2

HCID 6453965Benzaldehyde, 3-(2-hydroxyethoxy)-

HCID 57936477N-(Pyrrolidin-3-yl)isoquinolin-5-amine

生成物 1

HCID 250083272-(3-((3-(Isoquinolin-5-ylamino)pyrrolidin-1-yl)methyl)phenoxy)ethanol

実験手順

Reaction of N-(pyrrolidin-3-yl)isoquinolin-5-amine with 3-(2-hydroxyethoxy)benzaldehyde using the method of Example 8 afforded the title compound.

出典と根拠

ORDレコード: ord-e69c79c057754bb595f005216ee6a5d2
出典データセット: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08071779B2

反応ノート

読み込み中…