Ethanol → (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

HRID 656761ノート

反応式

HRID 656761 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:19][C:20]([OH:22])=[O:21])[CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:28][CH2:29]O>>[CH2:28]([O:21][C:20](=[O:22])[CH2:19][C:11]1[CH:12]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1)[CH3:29]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 59644613(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid

生成物 1

HCID 58148866(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

実験手順

To (3-benzyloxy-5-trifluoromethyl-phenyl)-acetic acid (1.5 g, 5.4 mmol) in EtOH (30 mL) was added sulfuric acid (1 mL), and the mixture was stirred overnight at room temperature. Once no starting material was seen by analytical LCMS, the reaction was worked up to give (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester.

出典と根拠

ORDレコード
ord-d50d6bb9fe8b4fe5bd7d7a5a31a826ea
出典データセット
uspto-grants-2011_12
特許番号
US08071807B2

反応ノート

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