2-Chloroethylamine → 4-(2-aminoethyl)-2,6-dimethyl-8-ethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

反応式

[CH3:1][C:2]1[CH:21]=[C:5]2[NH:6][C:7](=[O:20])[C:8]3[C:13]([CH3:14])=[N:12][C:11]4[N:15]([CH2:18][CH3:19])[N:16]=[CH:17][C:10]=4[C:9]=3[N:4]2[N:3]=1.Cl[CH2:23][CH2:24][NH2:25].CN(CCCCl)C>>[NH2:25][CH2:24][CH2:23][N:6]1[C:7](=[O:20])[C:8]2[C:13]([CH3:14])=[N:12][C:11]3[N:15]([CH2:18][CH3:19])[N:16]=[CH:17][C:10]=3[C:9]=2[N:4]2[N:3]=[C:2]([CH3:1])[CH:21]=[C:5]12

参加物

反応物 3

HCID 133692-Chloroethylamine

HCID 669603-Chloro-N,N-dimethyl-1-propanamine

HCID 1357053772,6-dimethyl-8-ethyl-4H-pyrazolo-[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

生成物 1

HCID 227574604-(2-aminoethyl)-2,6-dimethyl-8-ethyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

実験手順

By substituting the 2,6-dimethyl-8-ethyl-4H-pyrazolo-[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one obtained in Example 16 in the procedure of Example 4 and substituting 2-chloroethylamine for the dimethylaminopropyl chloride, 4-(2-aminoethyl)-2,6-dimethyl-8-ethyl-4H-pyrazolo-[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one is obtained.