p-Toluenesulfonic acid monohydrate → 7-Oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2-carbaldehyde
反応式
C[O:2][CH:3](OC)[C:4]1[N:5]=[CH:6][C:7]2[CH2:13][CH2:12][C:11](=[O:14])[NH:10][C:8]=2[N:9]=1.CC1C=CC(S(O)(=O)=O)=CC=1.O>CC1C=CC(S(O)(=O)=O)=CC=1.O.O.CC(C)=O>[O:14]=[C:11]1[NH:10][C:8]2[N:9]=[C:4]([CH:3]=[O:2])[N:5]=[CH:6][C:7]=2[CH2:13][CH2:12]1参加物
5
反応物 2
生成物 1
試薬・触媒・溶媒 2
実験手順
To a solution of 2-[bis(methyloxy)methyl]-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one (0.873 g, 3.91 mmol) in 1:1 H2O/acetone (10 mL) was added p-TsOH.H2O (0.074 g, 0.391 mmol) and the reaction was heated to 80° C. for 3 days with additional p-TsOH.H2O (0.20 g). After the disappearance of starting material, the solution was concentrated under vacuum to yield the desired product (1.023 g).
後処理
- concentrationAfter the disappearance of starting material, the solution was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-e21ec4b4e7b141b1b93c41537ae7fcca
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071592B2
反応ノート
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