Ammonia → 1-(2-carbamoylpropanoyl)-L-proline

反応式

C([O:3][C:4]([CH:6]([CH3:17])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])=O)C.[NH3:18]>>[C:4]([CH:6]([CH3:17])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=[O:3])[NH2:18]

参加物

反応物 2

HCID 222Ammonia

HCID 536785471-(2-ethoxycarbonylpropanoyl)-L-proline

生成物 1

HCID 542390101-(2-carbamoylpropanoyl)-L-proline

実験手順

1-(2-Ethoxycarbonylpropanoyl)-L-proline (2 g.) is dissolved in 10% methanolic ammonia and the mixture stored at room temperature in a pressure flask. When thin layer chromatographic analysis indicates that all the starting material has been converted to the amide, the mixture is concentrated to dryness, and the residual ammonium salt is converted to the free acid with ion exchange resin (Dowex 50 hydrogen form) to obtain 1-(2-carbamoylpropanoyl)-L-proline, yield 1.1 g.

後処理

customthe mixture stored at room temperature in a pressure flask
concentrationthe mixture is concentrated to dryness

出典と根拠

ORDレコード: ord-4b86951e21b84f2f89e44335ebe1a90c
出典データセット: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04128653

反応ノート

読み込み中…

参加物