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Hydrochloric Acid → N,3,5-tritert-butyl-4-hydroxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Tert-Butylamine | HCID 6385 | — |
| 反応物 | 3,5-Di-tert-butyl-4-hydroxybenzoyl chloride | HCID 3787187 | — |
| 溶媒 | Benzene hexane | HCID 110624 | — |
| 生成物 | N,3,5-tritert-butyl-4-hydroxybenzamide | HCID 1203452 | — |
反応手順
To a stirred solution of 13.43 g. (0.05 mole) of 3,5-di(t-butyl)-4-hydroxybenzoyl chloride in 50 ml. of dichloromethane is added dropwise 8.77 g. (0.12 mole) of t-butylamine. The mixture obtained is neutralized carefully with 10 percent hydrochloric acid and washed thrice with 200 ml. portions of water. The organic layer is dried, then evaporated under vacuum to provide a white residue. The residue is dissolved in hot benzene-hexane mixture and crystallized to provide 3,5-di(t-butyl)-4-hydroxy-N-t-butylbenzamide, m.p. 207°-208° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04128664 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-523687a5a331470bbda2d360c890f3dd |
| 出典メモ | uspto-grants-1978_12 |