Hydrochloric Acid → N,3,5-tritert-butyl-4-hydroxybenzamide

HRID 65723

反応式

HRID 65723 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]=1[OH:14])[C:8](Cl)=[O:9])([CH3:4])([CH3:3])[CH3:2].ClCCl.[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23].Cl>C1C=CC=CC=1.CCCCCC>[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:13]=1[OH:14])[C:8]([NH:26][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:9])([CH3:4])([CH3:3])[CH3:2]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 6385Tert-ButylamineHCID 37871873,5-Di-tert-butyl-4-hydroxybenzoyl chloride

生成物 1

HCID 1203452N,3,5-tritert-butyl-4-hydroxybenzamide

試薬・触媒・溶媒 1

HCID 110624Benzene hexane溶媒

実験手順

To a stirred solution of 13.43 g. (0.05 mole) of 3,5-di(t-butyl)-4-hydroxybenzoyl chloride in 50 ml. of dichloromethane is added dropwise 8.77 g. (0.12 mole) of t-butylamine. The mixture obtained is neutralized carefully with 10 percent hydrochloric acid and washed thrice with 200 ml. portions of water. The organic layer is dried, then evaporated under vacuum to provide a white residue. The residue is dissolved in hot benzene-hexane mixture and crystallized to provide 3,5-di(t-butyl)-4-hydroxy-N-t-butylbenzamide, m.p. 207°-208° C.

後処理

  1. customThe mixture obtained
  2. washwashed thrice with 200 ml
  3. customThe organic layer is dried
  4. customevaporated under vacuum
  5. customto provide a white residue
  6. customcrystallized

出典と根拠

ORDレコード
ord-523687a5a331470bbda2d360c890f3dd
出典データセット
uspto-grants-1978_12
特許番号
US04128664

関連ノート

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