Acetic Anhydride → [5-[4-(Dimethylamino)butyl]-2-furanyl]methyl ethanoate

HRID 65738ノート

反応式

HRID 65738 の反応式
[CH3:1][N:2]([CH3:14])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[O:11][C:10]([CH2:12][OH:13])=[CH:9][CH:8]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16].C([O-])(=O)C.[Na+]>C1C=CC=CC=1.O>[C:15]([O:13][CH2:12][C:10]1[O:11][C:7]([CH2:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:1])[CH3:14])=[CH:8][CH:9]=1)(=[O:17])[CH3:16]

参加物

6

反応物 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 23452131HCID 23452131、化合物

生成物 1

HCID 23452115[5-[4-(Dimethylamino)butyl]-2-furanyl]methyl ethanoate

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 962Water溶媒

実験手順

A mixture of 5-[4-(dimethylamino)butyl]-2-furanmethanol (4.9 g), acetic anhydride (25 g) and fused and powdered sodium acetate (10 g) in benzene (25 ml) was stirred at room temperature for 24 hr. The reaction was diluted with water (100 ml) and extracted with ethyl acetate. The combined extracts were distilled to afford a clear colourless oil b.p. 100°, 0.5 mm Hg. Found: C, 65.62; H, 9.03; N, 5.95. Calc. for C13H21NO3 : C, 65.24; H, 8.85; N, 5.85%.

後処理

  1. extractionextracted with ethyl acetate
  2. distillationThe combined extracts were distilled

出典と根拠

ORDレコード
ord-c2378da5ae4843158432c6149734716a
出典データセット
uspto-grants-1978_12
特許番号
US04128658

反応ノート

読み込み中…