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Cysteamine Hydrochloride → 5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cysteamine Hydrochloride | HCID 9082 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 5-((Dimethylamino)methyl)-2-furanmethanol | HCID 84906 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine | HCID 162203 | 54.2% |
反応手順
5-(Dimethylamino)methyl-2-furanmethanol (15.5 g) was added dropwise to a stirred, ice-cold solution of cysteamine hydrochloride (11.36 g) in concentrated hydrochloric acid (40 ml). After standing at 0° for 18 hr, excess anhydrous sodium carbonate was added and the resultant solid extracted with diethyl ether. Removal of solvent followed by distillation of the residue gave 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine (11.6 g) b.p. 104-106° (0.1 mm). Picrate salt m.p. 142-144°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04128658 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-cc38c10a1e61412ba61a5b78e5106f8d |
| 出典メモ | uspto-grants-1978_12 |