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N-Ethylphthalimide → 2-[[2-(2-Furanyl)ethyl]thio]ethyl-1H-isoindole-1,3(2H)-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Ethylphthalimide | HCID 21120 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | p-Toluenesulfonate | HCID 85570 | — |
| 反応物 | 2-Phthalimidoethanethiol | HCID 96248 | — |
| 反応物 | 2-Furanethanol | HCID 642110 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[[2-(2-Furanyl)ethyl]thio]ethyl-1H-isoindole-1,3(2H)-dione | HCID 23452113 | — |
反応手順
80% Sodium hydride (0.155 g) was added portionwise to a solution of 2-phthalimido-ethanethiol (1.03 g) in dry dimethylformamide at 0°. After 20 mins a solution of 2-furanethanol, 4-methylbenzenesulphonate (1.33 g) in dry dimethylformamide was added dropwise and the solution stirred overnight at room temperature. The mixture was poured into ice-water and 2-[[2-furanyl)ethyl]thio]ethyl-1H-isoindole-1,3(2H)-dione isolated as a white solid (1.3 g) m.p. 53°-55°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04128658 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-baeb90febdf644ea825266bb67981a7b |
| 出典メモ | uspto-grants-1978_12 |