反応式
[H-].[Na+].[C:3]1(=[O:16])[N:7]([CH2:8][CH2:9][SH:10])[C:6](=[O:11])[C:5]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:4]12.[O:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][CH2:23]O.CC1C=CC(S([O-])(=O)=O)=CC=1.C(N1C(=O)C2C(=CC=CC=2)C1=O)C>CN(C)C=O>[O:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][CH2:23][S:10][CH2:9][CH2:8][N:7]1[C:6](=[O:11])[C:5]2[C:4](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]1=[O:16]参加物
7
実験手順
80% Sodium hydride (0.155 g) was added portionwise to a solution of 2-phthalimido-ethanethiol (1.03 g) in dry dimethylformamide at 0°. After 20 mins a solution of 2-furanethanol, 4-methylbenzenesulphonate (1.33 g) in dry dimethylformamide was added dropwise and the solution stirred overnight at room temperature. The mixture was poured into ice-water and 2-[[2-furanyl)ethyl]thio]ethyl-1H-isoindole-1,3(2H)-dione isolated as a white solid (1.3 g) m.p. 53°-55°.
出典と根拠
- ORDレコード
- ord-baeb90febdf644ea825266bb67981a7b
- 出典データセット
- uspto-grants-1978_12
- 特許番号
- US04128658
関連ノート
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