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5-((Dimethylamino)methyl)-2-furanmethanol → 2-[[5-(Dimethylamino)methyl-2-furanyl]methoxy]ethanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-((Dimethylamino)methyl)-2-furanmethanol | HCID 84906 | — |
| 反応物 | 2-Chloroethylamine hydrochloride | HCID 9793737 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[[5-(Dimethylamino)methyl-2-furanyl]methoxy]ethanamine | HCID 20213312 | — |
反応手順
A solution of 2-chloroethylamine hydrochloride (6.25 g) in dry dimethylformamide was added dropwise to a stirred, cooled solution of potassium tert-butoxide (8.96 g) and 5-(dimethylamino)methyl-2-furanmethanol (12.4 g) in the same solvent. After 2 hr solvent was removed, the residue basified and extracted with ethyl acetate. The residue after removal of solvent was treated in ethanol with ethanolic oxalic acid. The crystalline salt was recrystallised from ethanol to give 2-[[5-(dimethylamino)methyl-2-furanyl]methoxy]ethanamine, bis oxalate, m.p. 130°-133° (3.05 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04128658 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-31301e6e1b0b47f1a66e9b48bc759747 |
| 出典メモ | uspto-grants-1978_12 |