Ethanol → HCID 178469094、化合物
反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.S(=O)(=O)(O)O.[CH2:16](O)[CH3:17]>>[CH2:16]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[N:3][CH:4]=1)[CH3:17]参加物
4
実験手順
To a 100 mL three-necked flask, 0.84 g (0.006 mol) of 6-hydroxynicotinic acid, 30 mL of anhydrous ethanol were added, 3 mL of concentrated sulfuric acid was added dropwise slowly, refluxed overnight, evaporated under vacuum to remove excessive ethanol, the residue was poured into water, extracted with ethyl acetate, washed with saturated sodium hydrogen carbonate, dried with anhydrous sodium sulfate, and concentrated to obtain 0.8 g of 6-hydroxy-nicotinic acid ethyl ester. Yield: 80%.
後処理
- temperaturerefluxed overnight
- customevaporated under vacuum
- customto remove excessive ethanol
- additionthe residue was poured into water
- extractionextracted with ethyl acetate
- washwashed with saturated sodium hydrogen carbonate
- dry with materialdried with anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-cceb857afbcd4c9baf619af6d8f86756
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076339B2
反応ノート
読み込み中…