Potassium Carbonate → 4'-(3-Chloropropoxy)biphenyl-1-carboxylic acid ethyl ester
反応式
[CH2:1]([O:3][C:4]([C:6]1([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH2:7]1)=[O:5])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Br[CH:26](O)[CH2:27][CH2:28][Cl:29]>CN(C)C=O>[CH2:1]([O:3][C:4]([C:6]1([C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:26][CH2:27][CH2:28][Cl:29])=[CH:16][CH:17]=2)[CH:7]=[CH:8][CH:9]=[CH:10][CH2:11]1)=[O:5])[CH3:2]参加物
5
実験手順
Following the procedure described in example 47§D, but starting from 4′-hydroxybiphenyl-1-carboxylic acid ethyl ester (3 g), potassium carbonate (8.55 g) and 1-bromo-3-chloropropanol (6 mL) in N,N-dimethylformamide (30 mL) affords 4′-(3-chloropropoxy)biphenyl-1-carboxylic acid ethyl ester in quantitative yield used without further purification.