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Triphenylphosphine → HCID 23150257、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Oxalate | HCID 71081 | — |
| 反応物 | 1-(Prop-2-yn-1-yl)piperidine | HCID 336652 | — |
| 反応物 | 1-{3-[(4'-Bromobiphenyl-4-yl)oxy]propyl}piperidine | HCID 23150313 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | HCID 23150257 | HCID 23150257 | 21.4% |
反応手順
Following the procedure described in example 43§C, but starting from 1-{3-[(4′-bromobiphenyl-4-yl)oxy]propyl}piperidine (0.75 g), 1-prop-2-yn-1-ylpiperidine (320 mg), triethylamine (20 mL), cuprous iodide (4.2 mg), triphenylphosphine (20 mg) and bis(triphenylphosphinepalladiumdichloride) affords 179 mg of 1-(3-{[4′-(3-piperidinoprop-1-yn-1-yl)biphenyl-4-yl]oxy}propyl)piperidine which oxalate melts at 195° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08076329B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-8ac4ff95480b4bbaaaf4254bd7871ada |
| 出典メモ | uspto-grants-2011_12 |