Hydrochloric Acid → 6-Ethynyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
反応式
[CH3:1][C:2]1[C:7]([C:8]#[C:9][Si](C)(C)C)=[C:6]([NH2:14])[N:5]2[N:15]=[CH:16][N:17]=[C:4]2[N:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl>CO.O1CCCC1.O>[C:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]2[N:5]([N:15]=[CH:16][N:17]=2)[C:6]=1[NH2:14])#[CH:9]参加物
5
実験手順
A mixture of Example 72A (122 mg, 0.5 mmol), potassium carbonate (138 mg, 1.0 mmol) in a mixed solvent of methanol/tetrahydrofuran/H2O(3 mL/3 mL/0.5 mL) was stirred at room temperature for 1.5 h. The reaction mixture was acidified with 1N HCl. The solid was filtered, washed with water and ethyl acetate to provide the title compound as an off-white solid (35 mg, 40% yield).
後処理
- filtrationThe solid was filtered
- washwashed with water and ethyl acetate
出典と根拠
- ORDレコード
- ord-a647cc33e857455c9159cda5f8fb8ce0
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076344B2
反応ノート
読み込み中…