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Iodoethane → N-Ethylphenothiazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Phenothiazine | HCID 7108 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 触媒 | Tetrabutylammonium hydrogen sulfate | HCID 94433 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-Ethylphenothiazine | HCID 219178 | — |
反応手順
A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07083884B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-625c6e1d30dd4d0a9f0e4279bcd0f5ff |
| 出典メモ | uspto-grants-2006_08 |