Isopropyl Acetate → 2-Methoxypyrimidine-5-carboxaldehyde
反応式
S(O)(O)(=O)=O.[CH3:6][O:7][C:8](=[NH:10])[NH2:9].C[O:12][C:13](=N)N.C[NH+]([CH2:19][C:20](CN(C)C)=[CH:21][NH+](C)C)C.C(OC(C)C)(=O)C.C(=O)(O)[O-].[K+]>O>[CH3:6][O:7][C:8]1[N:9]=[CH:21][C:20]([CH:13]=[O:12])=[CH:19][N:10]=1参加物
6
実験手順
To a stirred slurry of O-methylisourea hemisulfate (1.08 g, 4.13 mmol), vinamidinium salt (3.00 g, 8.26 mmol), 1-methylethyl acetate (16.0 mL, 137 mmol) was added a solution of potassium bicarbonate (1.17 g, 11.6 mmol) in water (5.0 mL) over a 10 minutes period. After completion of the addition the resulting reaction mixture was stirred at room temperature for 40 hours. The mixture was diluted with water (20 mL) and extracted with EtOAc (2×25 mL). The combined organic layers were dried over sodium sulfate and concentrated to yield a white solid.
後処理
- additionAfter completion of the addition
- customthe resulting reaction mixture
- extractionextracted with EtOAc (2×25 mL)
- dry with materialThe combined organic layers were dried over sodium sulfate
- concentrationconcentrated
- customto yield a white solid
出典と根拠
- ORDレコード
- ord-fe6c5ecaa1a94111831f0dae382a8cf6
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076345B2
反応ノート
読み込み中…