Triethylamine → 7-(Trifluoromethyl)quinoline

HRID 657768

反応式

HRID 657768 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.C(N(CC)CC)C>[Pd].CO>[F:15][C:12]([F:13])([F:14])[C:8]1[CH:7]=[C:6]2[C:11]([CH:2]=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

参加物

5

反応物 2

HCID 8471TriethylamineHCID 676684-Chloro-7-(trifluoromethyl)quinoline

生成物 1

HCID 4596147-(Trifluoromethyl)quinoline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

4-Chloro-7-(trifluoromethyl)quinoline (9.35 g, 0.0404 mol) was hydrogenated in the presence of 5% palladium on carbon (4 g) in methanol (180 mL) in the presence of triethylamine (6 mL). The solution was stirred for 3.5 hours, and then filtered through Celite. The filtrate was concentrated under reduced pressure, and the residue was treated with ethyl acetate and water. The organic layer was separated, washed with water (2×75 mL), dried over MgSO4, filtered, and concentrated under reduced pressure to a yellow solid.

後処理

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. additionthe residue was treated with ethyl acetate and water
  4. customThe organic layer was separated
  5. washwashed with water (2×75 mL)
  6. dry with materialdried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure to a yellow solid

出典と根拠

ORDレコード
ord-7e1175e3eff24a31a75d8f8b247a79c0
出典データセット
uspto-grants-2011_12
特許番号
US08076345B2

関連ノート

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