反応式
Br.Cl[C:3]1[CH:4]=[C:5]([CH3:13])[C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1.[O-:14][CH2:15][CH3:16].[Na+]>C(O)C>[CH2:15]([O:14][C:3]1[CH:4]=[C:5]([CH3:13])[C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1)[CH3:16]参加物
4
反応条件
- 温度
- 60 °C
実験手順
6-Chloro-8-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.002; 2.5 g) were dissolved in ethanol (50 ml), admixed under argon with sodium ethoxide (3.86 g) and stirred at 60° C. for 1 h. Then the mixture was dried and the residue was purified using a 40 g silica gel cartridge (0-20% dichloromethane-ethanol gradient in 40 min). The clean product fractions were combined and dried. 1.76 g of the title compound were obtained.
後処理
- customThen the mixture was dried
- customthe residue was purified
- customa 40 g silica gel cartridge (0-20% dichloromethane-ethanol gradient in 40 min)
- customdried
出典と根拠
- ORDレコード
- ord-cc3a1c9771c64979ba276fe96faaabe4
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076336B2
関連ノート
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