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Isopropanol → 6-Isopropoxy-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 6-Chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-B]pyridazin-3-amine | HCID 58045804 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-Isopropoxy-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine | HCID 58046064 | — |
反応手順
Isopropanol (27 ml) was deprotonated analogously to W1.056 with sodium hydride (1.3 g) and reacted with 6-chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W2.006a, 1 g), dissolved in isopropanol (10 ml) and DMF (10 ml), and worked up. 847 mg of the title compound were isolated in sufficient purity.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08076336B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-61b0657902af4d33818a9695c6329057 |
| 出典メモ | uspto-grants-2011_12 |