1,1-Dimethylhydrazine → alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid

HRID 65796

反応式

HRID 65796 の反応式
[N:1]([CH:4]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([O:7]CC)=[O:6])=[C:2]=[O:3].[CH3:15][N:16]([CH3:18])[NH2:17].C(Cl)Cl>C(O)(=O)C>[CH3:15][N:16]([CH3:18])[NH:17][C:2]([NH:1][CH:4]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([OH:7])=[O:6])=[O:3]

参加物

5

反応物 3

HCID 59761,1-DimethylhydrazineHCID 6344DichloromethaneHCID 54068691alpha-Isocyanato-2-thiopheneacetic acid, ethyl ester

生成物 1

HCID 54530029alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 4.2 g. (0.02 mole) of DL-α-isocyanato-2-thiopheneacetic acid, ethyl ester and 1.2 g. (0.02 mole) of N,N-dimethylhydrazine in 80 ml. of methylene chloride is stirred overnight. The solution is concentrated and to the syrupy residue are added 10 ml. of 2N sodium hydroxide solution. After stirring for 30 minutes, a clear yellow solution results. By the addition of acetic acid, 3.9 g. of α-dimethylhydrazinocarbonylamino-2-thiopheneacetic acid are obtained, m.p. 208°-210°.

後処理

  1. concentrationThe solution is concentrated and to the syrupy residue
  2. additionare added 10 ml
  3. customa clear yellow solution results

出典と根拠

ORDレコード
ord-208d1fa98d07437e8ee5455d106b3405
出典データセット
uspto-grants-1978_12
特許番号
US04128724

関連ノート

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