Carbonochloridothioic acid, S-phenyl ester → HCID 85920205、化合物

HRID 65798

反応式

HRID 65798 の反応式
[NH2:1][C:2]([CH3:6])([CH3:5])[C:3]#[N:4].[C:7]1([S:13][C:14](Cl)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O1CCOCC1>[C:3]([C:2]([NH:1][C:14](=[O:15])[S:13][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[CH3:5])#[N:4]

参加物

4

反応物 2

HCID 83493Carbonochloridothioic acid, S-phenyl esterHCID 880222-Amino-2-methylpropionitrile

生成物 1

HCID 85920205HCID 85920205、化合物収率 30.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

3.4 g. (0.04 mole) of 2-amino-2-methylpropanonitrile are dissolved in 10 ml. of dioxane and a solution of 3.2 ml. (0.2 mole) of (phenylthio)carbonyl chloride in 10 ml. of dioxane is added. After stirring for one hour at room temperature, the reaction mixture is filtered, the filtrate is concentrated, and the solid residue is recrystallized from a small amount of toluene to yield 2.7 g of (1-cyano1-methylethyl)carbamothioic acid, S-phenyl ester; m.p. 152°-155°.

後処理

  1. filtrationthe reaction mixture is filtered
  2. concentrationthe filtrate is concentrated
  3. customthe solid residue is recrystallized from a small amount of toluene

出典と根拠

ORDレコード
ord-f4ecdca4ae7c4dfea97c7b618470ddd7
出典データセット
uspto-grants-1978_12
特許番号
US04128723

関連ノート

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