化工社化工社 化学情報印刷レポート · 研究参考用
Acetic Acid → 2,3,6-Trimethylcyclohex-2-en-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Ethyl ketone | HCID 7288 | — |
| 反応物 | 2-Butanone, 4-methoxy- | HCID 138889 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2,3,6-Trimethylcyclohex-2-en-1-one | HCID 3016843 | — |
| 生成物 | 4-Methyl-3-ethyl-2-cyclohexen-1-one | HCID 12540304 | — |
反応手順
152 g of 1-methoxybutan-3-one is dripped in the course of one hour into a boiling mixture of 400 g of diethyl ketone and 5 g of a 30% by weight solution of sodium methylate in methanol. The whole is then heated under reflux for another hour. The reaction mixture is neutralized with glacial acetic acid and then fractionated. 70 g of 2,3,6-trimethyl-2-cyclohexen-1-one and 9 g of 4-methyl-3-ethyl-2-cyclohexen-1-one is obtained. The total yield of cyclohexenone is 57% with reference to 1-methoxybutan-3-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04128728 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-96916d45f8224df5aabf38ffeaf9fe8d |
| 出典メモ | uspto-grants-1978_12 |